1 Inflammation

• 1.1 Principles of inflammation
  • 1.1.1 The response to injury and infection
  • 1.1.2 Factors involved in cell damage
  • 1.1.3 The phases of inflammation
• 1.2 Exudation and swelling
  • 1.2.1 Fluid exudate
  • 1.2.2 Cellular exudate
• 1.2 Cells participating in inflammation
  • 1.3.1 Mast cells and basophils
  • 1.3.2 Eosinophils
  • 1.3.3 Neutrophils, central cells in acute inflammation
    • 1.3.3.1 Neutrophil granules
    • 1.3.3.2 Neutrophils in host defence
    • 1.3.3.3 Neutrophils and host tissue damage
    • 1.3.3.4 Free radicals produced by neutrophils
    • 1.3.3.5 Regulation of neutrophil function
  • 1.3.4 Macrophages and monocytes
    • 1.3.4.1 Heterogeneity and activation of macrophages
    • 1.3.4.2 Biological functions of macrophages
    • 1.3.4.3 The role of macrophages in angiogenesis
• 1.4 Mediators of inflammation
  • 1.4.1 Histamine and serotonin
  • 1.4.2 Lipid mediators
  • 1.4.3 Products of the complement system
  • 1.4.4 The coagulation mechanism
  • 1.4.5 Fibrinolysis
  • 1.4.6 The kinin-forming system
  • 1.4.7 Cytokines mediating inflammatory and effector functions
    • 1.4.7.1 Chemokines
  • 1.4.8 Chemotactic factors
  • 1.4.9 The acute phase reactants
• 1.5 Molecular mechanisms of the acute cell-mediated inflammatory reaction
  • 1.5.1 Adhesion molecules
  • 1.5.2 Leukocyte mobility and chemotaxis
• 1.6 Categories of inflammation mediated by the immune system
  • 1.6.1 Allergic (reaginic) acute inflammation
  • 1.6.2 Acute inflammation mediated by cytotoxic antibodies
  • 1.6.3 Acute inflammation mediated by immune complexes
  • 1.6.4 Chronic inflammation (delayed-type of hypersensitivity reaction)