2.3 Causes of fever

Such a change is considered to be a cause of fever that initiates the production of endogenic pyrogens. Generally, these changes may be divided into several groups:

1. infections caused by bacteria, ricketsia, chlamydia, viruses, and parasites
2. immune reactions, including the defects in collagen, immunological abnormalities and acquired immunodeficiency
3. destruction of tissues, such as trauma, local necrosis (infarction), and inflammatory reaction in tissues and vessels (flebitis, arteritis), pulmonary infarction, cerebral and myocardial infarction, and rhabdomyolysis
4. specific inflammations (sarcoidosis, granulomatous hepatitis)
5. inflammation of intestine and intraabdominal inflammatory processes
6. neoplastic processes with the participation of lymphoendothelial system and hemopoetic system, solid tumours (Grawitz tumour of the kidney, carcinoma of the pancreas, pulmonary and skeletal tumours, hepatoma) Fever is present in complications of solid tumours, usually in metastases that are associated with necrosis of the tumour, obstruction of ducts, or with infection
7. acute metabolic failures such as arthritis urica, porfyria, Addison's crisis, thyreotoxic crisis, and feochromocytoma
8. administration of some drugs
9. dehydration or admistration of salts. That's why fever occurs together with diarrhea.
10. administration of foreign proteins (e.g. globulinum antitetanicum-antitoxic fraction of horse serum) may be the reason of fever's origin.